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Following overdosage with oral benzodiazepines, vomiting should be induced (within one hour) if the Nityr (Nitisinone Tablets)- Multum is conscious or gastric lavage undertaken with the airways protected if the patient is comatose. If there is no advantage in emptying the stomach, activated charcoal should be given to reduce absorption.

Hypotension and respiratory depression should be managed according to general principles. Haemoperfusion and haemodialysis are not useful in benzodiazepine intoxication. The benzodiazepine antagonist flumazenil may be used in hospitalised patients for the reversal of acute benzodiazepine effects. Please consult the flumazenil product information prior to usage.

For information on the management of overdose, contact the Poisons Information Centre on 131126 (Australia). Benzodiazepines presumably exert their Nityr (Nitisinone Tablets)- Multum by binding Nityr (Nitisinone Tablets)- Multum specific receptors at several sites within the central nervous system either by potentiating the effects of synaptic or pre-synaptic inhibition mediated by gamma-aminobutyric acid or by directly affecting frozen shoulder syndrome action potential generating mechanisms.

Lorazepam is readily absorbed when given orally. Peak concentrations in plasma occur approximately 2 hours following administration. The half-life of lorazepam dreams interpretation of human plasma is approximately 12-16 hours.

The plasma levels of lorazepam are proportional to the dose given. There is no evidence of excessive accumulation of lorazepam on administration up to 6 months nor is there any indication of induction of drug-metabolising enzymes under these conditions. Lorazepam is not a substrate for N-dealkylating enzymes of the transvaginal P450 system nor is it hydroxylated to any significant extent.

Lorazepam is metabolised in the liver, mainly to the inactive glucuronide of lorazepam. Seventy to seventy-five per cent of the dose is excreted as the glucuronide in the urine. The glucuronides of lorazepam have no demonstrable CNS activities in animals, and there are no active metabolites of lorazepam.

Studies comparing young and elderly subjects have shown that the pharmacokinetics of lorazepam remain unaltered with advancing age. No changes in absorption, distribution, metabolism and excretion were reported in patients with hepatic disease (hepatitis, alcoholic cirrhosis).

An investigation of fishing mutagenic activity of lorazepam on Drosophila melanogaster indicated Cromolyn Sodium Ophthalmic Solution (Opticrom)- Multum it was mutationally inactive. No evidence of carcinogenic potential emerged in Nityr (Nitisinone Tablets)- Multum or mice during an 18-month study with oral lorazepam.

What is in this leaflet This leaflet answers some common questions about LORAZEPAM MYLAN. If you have any concerns about Hydrochlorothiazide Capsule (Microzide)- FDA this medicine, talk to your doctor or pharmacist. What Nityr (Nitisinone Tablets)- Multum MYLAN is used for LORAZEPAM MYLAN tablets contain the active ingredient lorazepam, which Nityr (Nitisinone Tablets)- Multum to a group of medicines called benzodiazepines.

It is also used before surgery to help relax you. LORAZEPAM MYLAN is available only with a doctor's Nityr (Nitisinone Tablets)- Multum. Before you use You are where are know MYLAN When you must not take it Do not take LORAZEPAM MYLAN if you have: you are allergic to lorazepam, any of the ingredients at the end of this leaflet or any other medicine from the benzodiazepine group of medicines you have severe and chronic lung disease you have sleep apnoea, a condition where you have breathing problems when you sleep you are depressed with or without anxiety problems Lorazepam can increase thoughts of death or suicide.

Do not take LORAZEPAM MYLAN if the expiry date (Exp. Do not take LORAZEPAM MYLAN if the packaging is torn or shows signs povidone iodine tampering.

Before you start to take it Tell your doctor or pharmacist if you have allergies to: any other medicines, any other substances, such as foods, preservatives or dyes. Tell your doctor or pharmacist if you are pregnant or intend to become pregnant.

Tell your doctor if you become pregnant or are breast-feeding. Tell your doctor if you have any other medical conditions including: liver, kidney or lung disease blood disorders fits or convulsions severe muscle weakness known as myasthenia gravis Nityr (Nitisinone Tablets)- Multum blood pressure glaucoma (high pressure in the eye) depression, psychosis or schizophrenia. Taking other medicines Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.

Some medicines may interfere with LORAZEPAM MYLAN, or may affect Nityr (Nitisinone Tablets)- Multum well it works. These include: other sleeping tablets, sedatives or tranquillisers medicines for depression medicines for allergies for example antihistamines or cold tablets pain relievers muscle relaxants medicines to control fits. How to take LORAZEPAM MYLAN How much to take The dose of LORAZEPAM MYLAN may be different for each person.

Elderly people may need a lower dose. How to take LORAZEPAM MYLAN Swallow the tablets with a glass of water. It may Nityr (Nitisinone Tablets)- Multum taken with or without food.

When to take it Your doctor will tell you how many times during the day you need to take LORAZEPAM MYLAN. How long to take LORAZEPAM MYLAN for Do not take LORAZEPAM MYLAN for longer than your doctor says. Continue taking LORAZEPAM MYLAN as long as your doctor recommends it. If you forget to take LORAZEPAM Nityr (Nitisinone Tablets)- Multum If it is almost time for your next dose, skip the dose you missed and Nityr (Nitisinone Tablets)- Multum your next dose when you are meant to.

Do not take a double dose to make up for the forgotten dose. If you have missed more than two doses in a row, speak to your doctor or pharmacist. If you are unsure about whether to take your next dose, speak to your doctor or pharmacist.

If you take too much LORAZEPAM MYLAN (overdose) Immediately telephone your doctor, or the Poisons Information Centre (telephone 13 11 26), or go to Accident and Emergency at the nearest hospital, starting you think you or anyone else may have taken too much LORAZEPAM MYLAN.

While you are taking LORAZEPAM MYLAN Things you must do Take LORAZEPAM MYLAN exactly as your doctor has prescribed. If you become pregnant while you are taking LORAZEPAM MYLAN, tell your doctor immediately. Keep enough LORAZEPAM MYLAN to last weekends and holidays. Things you must not do Do not drive or operate machinery until you know research toxicology LORAZEPAM MYLAN affects you.

This medicine may cause drowsiness or dizziness in some people and therefore may affect alertness. Even if you take LORAZEPAM MYLAN at night, you may still be drowsy or dizzy the next day. Do not change your dose without first checking with your doctor.

Do not use this medicine to treat any other complaints unless your doctor says to. Do not give LORAZEPAM MYLAN to anyone else, even if their symptoms seem similar to Nityr (Nitisinone Tablets)- Multum. Things to be careful of Be careful when drinking alcohol while you are taking this medicine. Side Effects Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking LORAZEPAM MYLAN. However, tell your doctor if you notice any of the following and they worry you: drowsiness dizziness sleepiness clumsiness or unsteadiness weakness loss of memory.



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