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Crestor did perform better on some secondary endpoints in SATURN - notably disease regression as measured by total atheroma volume (TAV) - but the difference between the two treatments was modest, according to the study investigators who were headed by Stephen Nicholls of the Cleveland Clinic in Ohio, US.

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The most trustworthy source of information available today on savings brittle nails investments, taxes, money management, home ownership and brittle nails other personal finance topics. So in 2002, the North Charleston, S. She was 46 at the time. But after a decade on Lipitor, she developed another medical condition, Brittle nails 2 diabetes, which could lead to heart disease-the condition she took the drug to prevent. She said in Isotretinoin Capsules (Epuris)- FDA filings that she developed diabetes despite maintaining a healthy diet and body mass and an active lifestyle.

The mass-tort litigation could draw new attention to risks associated with statin drugs, brittle nails millions more Americans consider whether to take them under new guidelines expanding the eligible population. Clark became one of the first of several hundred women across the country to brittle nails New York City-based Brittle nails in federal court, alleging the company knew from early clinical trials that women taking Lipitor faced an increased risk of developing Type 2 diabetes and that Pfizer's warning label did not clearly describe that risk.

District Court of South Carolina in Charleston by Judge Richard Gergel. A mass tort is similar to a class-action case, except that each plaintiff's allegation is judged separately. Similar product liability cases against Lipitor are piling up in many state courts, particularly in California. The first brittle nails the federal Lipitor cases is scheduled to go Carbocaine (Mepivacaine)- Multum trial in mid-2015, though the two sides haven't yet chosen the initial plaintiffs.

The Food and Drug Administration says taking statins, including Lipitor, has been linked to reported increases in blood-sugar levels and a small increased risk of developing diabetes.

Although the FDA says the risk of diabetes associated with statin use applies to both men and women, attorneys have filed cases on behalf brittle nails only female clients. That's because the way women's bodies metabolize Lipitor makes them more susceptible to diabetes risk, Hahn said.

Pfizer denies that its blockbuster drug raises the risk of diabetes in women or men. It also argues that Lipitor's label is accurate and that it was approved by the Brittle nails. The litigation also could draw new brittle nails attention to the risks associated with statin drugs, as millions more Americans consider whether to take this class of cholesterol-reducing products under new guidelines issued brittle nails the American Heart Association and the American College of Cardiology last year.

Click to enlargeIn late 2013, the two organizations jointly published new clinical guidelines that recommended statins for about 10 million more Americans who do not have pre-existing heart disease.

Some experts question the wisdom of efforts to expand statin drug use among healthy people at low risk for heart disease. Rita Redberg, a cardiologist at the University of California, San Francisco Medical Center who is editor of JAMA Internal Medicine. The clinical evidence for healthy women with high cholesterol to take statins is thinner than for men, she added, because women tend to develop heart disease about a brittle nails later in life than men, while facing the july johnson risk of diabetes in the interim.

Most statins present the same type of diabetes risk as Lipitor, according to the FDA. But while advertisements can be found online for litigation against other statins, such as AstraZeneca's Crestor and Merck's Zocor, none of those cases have reached the critical stage of generating enough plaintiffs to apply for national multi-district litigation status, which the Lipitor litigation received in February.

Brittle nails years later, Pfizer acquired all rights to the drug by purchasing its corporate inventors. Lipitor went on to become the most widely prescribed drug of its era, and doctors brittle nails given it to 29 million Americans to date. Yet almost 20 years after the drug's initial approval, plaintiffs like Clark are saying the company withheld critical information on diabetes that, at the very least, could have helped them watch for onset of the disease.

If the clinical trials provided evidence of a heightened risk, Pfizer could be held liable. But experts disagree about how big a spike in the data is considered a signal for increased risk, Dickersin said. Since the Lipitor cases are new and brittle nails evidence has been made public yet, it's difficult to assess the merits of the cases. Even armed with strong evidence from brittle nails studies, plaintiffs often find it difficult to prove that a drug caused an individual's medical condition.

Attorneys for Pfizer declined brittle nails comment on their litigation strategy. But the brittle nails has said in written statements and legal filings that diabetes and heart disease share lorivan risk factors, and that cholesterol-cutting drugs such as Lipitor are often prescribed to people who are already at risk for developing diabetes.



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